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CCC-TRIO Symposium

Translational Research In Oncology

CCC-TRIO 2025 - Translational Research In Oncology

Symposium of the Comprehensive Cancer Center Vienna
12th - 13th June 2025, Vienna

Venue: Hörsaalzentrum, Medical University of Vienna/University Hospital Vienna
Währinger Gürtel 18 - 20
1090 Vienna

Join the Future of Oncology!

International Keynote Speakers

Friday, June 13th 2025
SESSION V: PRECISION LIQUID DIAGNOSTICS

4.00 - 4.35 pm: KEYNOTE: "The Utility of Liquid Biopsy in Immuno-Oncology: A Focus on Circulating Tumour Cells"

Catherine Alix-Panabières, University Medical Centre of Montpellier (CHU)

Thursday, June 12th 2025
SESSION III: COMPUTATIONAL BIOLOGY & MACHINE LEARNING IN CANCER
4.50 - 5.25 pm: KEYNOTE: "AI Model Accurately Predicts Endometrial Cancer Recurrence"

 

Thursday, June 12th 2025
SESSION II: TRENDS IN CANCER EPIDEMIOLOGY - EARLY ONSET CANCER
11.45 am – 12.15 pm: KEYNOTE: "Evidence for Rising Incidence Rates of Early Onset Colorectal Cancer – a Global Perspective"

Thursday, June 12th 2025
2.15 - 2.50 pm: KEYNOTE: "The Gemelli Clinic Vision on AI/Radiomics in Connection with Surgery"

© Federmann und Kampczyk design gmbh

SESSION I: WHAT´S NEXT IN IMMUNO ONCOLOGY?

9.15 - 9.50 am: KEYNOTE: "Concepts to Enable Immunotherapy in CRC"

Colorectal cancer (CRC) is the third most common type of cancer and one of the most
common cause for cancer-associated deaths in industrial nations. Carcinogenesis in
general is not a cell autonomous process, but a complex interplay of much more major
players than just mutagenized, cancer-initiating cells. Particularly in CRC the
reciprocal interaction of cells within the tumor microenvironment (TME) markedly
influences all stages of tumorigenesis, and the plasticity of both tumor cells and
surrounding cells within the TME is driven to a large extent by inflammation. So far,
all CRC tumors that have been studied are associated with an inflammatory
environment (either preceding tumorigenesis, tumor-elicited or therapy-induced)
and over the recent 5 years our knowledge of how tumor cells communicate with
their tumor microenvironment in order to modulate inflammatory immune responses
to their needs, for example in order to suppress and escape anti-tumorigenic immune
responses, has significantly improved. Thus, a detailed understanding of the molecular
and cellular basis defining the immune pathogenesis of CRC will undoubtedly lead to
the development of novel and more efficient multi-modal therapeutic strategies that
go beyond conventional therapies targeting tumor cells only. Recent findings
regarding the modulation of an adaptive immune during CRC pathogenesis and
therapy will be discussed.

Florian R. Greten, Georg Speyer Haus, Institute for Tumor Biology and Experimental Therapy

Friday, June 13th 2025
SESSION VI: NOVEL TARGETS FRESH FROM THE BENCH... TO THE BEDSIDE
11.00 - 11.35 am KEYNOTE: Douglas Hanahan, Ludwig Institute for Cancer Research, Lausanne, CH

 

Friday, June 13th 2025
SESSION IV: NOVEL THERAPEUTICS
9.00 – 9.35 am:
KEYNOTE: "Mode of Action – How to Choose the Right Target?"

Professor Thomas Powles is the Chair of Barts Cancer Centre, London.  He leads the Experimental Cancer Medicine Centre and Biomedical Research Cancer Grants at Barts/QMUL. He has led 23 randomised cancer trials including studies which resulted in multiple EMA and FDA approvals. He has led clinical and high impact translational science projects. He has an H-index of 100 and has given plenary presentations at the major cancer meeting. Barts. He co-leads the Uromigos podcast and European Guidelines for GU cancer. He is editor in chief of the Annals of Oncology Journal . In 2023 he was selected a Nature’s 10 global scientist and in 2024 TIME magazines 100 healthcare list . 

Program

Program, Thursday 12th June 2025

09.00 – 09.15 AM: WELCOME
Markus Müller, Rector of the Medical University Vienna
Shahrokh Shariat, Comprehensive Cancer Center Vienna


9.15 – 11.15 am: SESSION I
WHAT´S NEXT IN IMMUNO ONCOLOGY?

  • KEYNOTE: "Concepts to Enable Immunotherapy in CRC"
    Florian R. Greten, Georg Speyer Haus, Institute for Tumor Biology and Experimental Therapy, D
  • "Translating Immune Cell Therapies into the Clinic"
    Antonia Müller, Department of Transfusion Medicine and Cell Therapy, Medical University of Vienna/AKH Vienna
  • "Role of the Innate Immune Cells in Cancer"
    Victoria Stary, Department of Surgery Medical University of Vienna/AKH Vienna
  • "MISTRG-6: An Avatar Model for Colorectal Cancer and Precision Immunotherapy"
    Dietmar Herndler-Brandstetter, Center for Cancer Research, Medical University of Vienna
  • "Tumor Sialylation Controls Effective Anti-Cancer Immunity in Breast Cancer"
    Stefan Mereiter, Penninger Lab, Medical University of Vienna & IMBA – Institute of Molecular Biotechnology, Austria
  • "Harnessing Innate Immunity to Prevent and Treat Metastases"
    Maria Sibilia, Center for Cancer Research, Medical University of Vienna


11.15 - 11.45 am: Coffee Break


11.45 am – 1.15 pm: SESSION II
TRENDS IN CANCER EPIDEMIOLOGY - EARLY ONSET CANCER

  • KEYNOTE: "Evidence for Rising Incidence Rates of Early Onset Colorectal Cancer – a Global Perspective"
    Freddie Bray, IARC, Lyon, F
  • "Multi-Omics Research for Identification of Colorectal Cancer Biomarkers"
    Stefanie Brezina, Center for Cancer Research, Medical University of Vienna
  • "Primary Prevention und Public Health"
    Igor Grabovac, Center for Public Health, Medical University of Vienna
  • "Chronic Inflammation in Health and Cancer"
    Dominik Wolf, Department of Oncology, CCC Innsbruck, Medical University of Innsbruck


1.15 - 2.15 pm: Lunch


2.15 - 2.50 PM: KEYNOTE: "The Gemelli Clinic Vision on AI/Radiomics in Connection with Surgery"
Anna Fagotti, Policlinico Gemelli, Roma, IT


2.50 - 4.20 pm: PANEL DISCUSSION:
CANCER CARE POLICY & STRATEGY IN AUSTRIA

  • Michaela Fritz, Medical University of Vienna
  • Christina Dietscher, Federal Ministry for Social Affairs, Health, Care and Consumer Protection
  • Hemma Bauer, Federal Ministry of Education, Science and Research
  • Herwig Ostermann, The Austrian National Public Health Institute (Gesundheit Österreich GmbH, GÖG)
  • Shahrokh F. Shariat, Comprehensive Cancer Center Vienna


4.20 – 4.50 PM: Coffee Break


4.50 – 6.10 pm: SESSION III:
COMPUTATIONAL BIOLOGY & MACHINE LEARNING IN CANCER

  • KEYNOTE: "AI Model Accurately Predicts Endometrial Cancer Recurrence"
    Bosse Tjalling, Leiden University Medical Center (LUMC), Leiden, Netherlands
  • tbd


6.10 - 8.00 pm: Poster & Dinner | Viewing &  Discussion


– End of Day I –

Friday 13th June 2025

9.00 – 10.30 am: SESSION IV
NOVEL THERAPEUTICS

Chairs: Nicole Concin, Shahrokh Shariat

  • KEYNOTE: "Mode of Action – How to Choose the Right Target?"
    Thomas Powles, Queen Mary University of London, Barts Cancer Centre, UK
  • "Patient-Derived Models to Study Therapy Response in Bladder Cancer"
    Bernhard Englinger, Department of Urology, Medical University of Vienna/AKH Vienna
  • "ADC in Breast Cancer"
    Georg Pfeiler, Department of Gynecology, Medical University of Vienna/AKH Vienna

  • "Uncovering New Targets for Precision Oncology Using Innovative CRISPR Approaches"
    Michael Dengler, Clinical Department for Oncology,  Medical University of Graz

10.30 – 11.00 am: Coffee Break


11.00 am – 1.00 pm SESSION VI
NOVEL TARGETS FRESH FROM THE BENCH... TO THE BEDSIDE

Chairs: Lena Horvath, Walter Berger

  • KEYNOTE: Douglas Hanahan, Ludwig Institute for Cancer Research, Lausanne, CH
  • "Cancer Vaccines: Oncolytic Virus Therapy for Basal Cell Carcinoma"
    Christoph Höller, Department of Dermatology, Medical University of Vienna/AKH Vienna
  • "Rethinking our Approach to Cancer Metabolism to Deliver Patient Benefits"
    Saverio Tardito, Center for Cancer Research, Medical University Vienna
  • "How to Overcome Side Effects of Targeted EGFR Therapies"
    Thomas Bauer, Center for Cancer Research, Medical University Vienna
  • "Exploring Unknown Tumors: Strategies for Uncovering Targetable Vulnerabilities in BCOR-altered CNS Tumors"
  • Daniela Lötsch-Gojo, Department of Neurosurgery, Medical University of Vienna/AKH Vienna
  • "Microplastic and Cancer"
    Lukas Kenner, Department of Pathology, Medical University of Vienna/AKH Vienna


1.00 – 2.00 pm: Lunch


2.00 - 3.30 pm: BREAK OUT SESSION: 3 WORKSHOPS TO CHOOSE BY YOUNG CCC

I. "Building the ideal cancer biobank: What to sample, to use and to keep?"
Moderation: Karin Schelch

II. "Organoids as a model: Innovations and Perspectievs"
Moderation: Daniela Lötsch-Gojo

III. "Patient:innenpartizipation in EU Projekten" (in German Language)
Moderation: Petra Heffeter


5.30 - 4.00 pm: Coffee Break


4.00 - 5.50 pm: SESSION V
PRECISION LIQUID DIAGNOSTICS

  • KEYNOTE: "The Utility of Liquid Biopsy in Immuno-Oncology: A Focus on Circulating Tumour Cells"
    Catherine Alix-Panabières, Liquid Biopsy Laboratory, University Medical Centre of Montpellier (CHU), France
  • "Blood-based Open Chromatin Accessibility in Cancer Subtyping"
    Isaac Lazzeri, Diagnostic and Research Center for Molecular BioMedicine, Medical University Graz
  • "Comparing liquid and tissue comprehensive genomic profiling for clinical decision-making"
    Samantha Hasenleithner, Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria
  • "Diagnosis and Disease Monitoring of Pediatric Brain Tumors via Cerebrospinal Fluid?"
    Johannes Gojo, Department of Pediatrics, Medical University of Vienna/AKH Vienna
  • „LB in Neadjuvant Therapy Response und Relapse Control“
    Nicolai Hübner, Department of Urology, Medical University of Vienna/AKH (requested)
  • "Multi-marker Analysis of Circulating Tumor Cells"
    Eva Obermayr, Department of Gynecology, Medical University of Vienna/AKH


8.30 pm: NETWORKING EVENT

 

This event will be approved with 18 DFP Points by the Austrian Medical Chamber's training program (DFP).

Poster Award - Submission Deadline 11th May 2025

The CCC-TRIO aims to enhance scientific exchange and networking in the field of translational cancer research. To this end, CCC-TRIO will feature a poster session as one of its highlights. The CCC will award attractive prizes to the best three scientific posters.

Please submit your Poster Abstract until 11th May 2025 at connect@ccc.ac.at

Poster Session with poster walk  will take place on 12 June. Take the opportunity to present your research work to the experts, network and start new collaborations!

Scientific Committee

Walter Berger, Medical University of Vienna/Center for Cancer Research
Nicole Concin, Medical University of Vienna/ University Clinic for Gynecology
Stephan Polterauer, Medical University of Vienna/University Clinic for Gynecology
Shahrokh F. Shariat, Medical University of Vienna/University Clinic for Urology & CCC Vienna
Maria Sibilia, Medical University of Vienna/Center for Cancer Research
and the Board of the Young CCC Vienna.

Video: CCC-TRIO 2023

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