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Gastroesophageal Tumor Unit (CCC-GET)

Aktuell (Grundlagenforschung)

  • ALK gene status and protein expression in gastroesophageal adenocarcinomas and squamous cell carcinoma of the esophagus
  • Clinical role of peripheral blood platelets in angiogenesis and lymphangiogenesis of esophageal cancer
  • Evaluation of established prognostic factors as predictive factors for histological and PET-CT assessed response to neoadjuvant chemotherapy in esophageal cancer
  • Molecular profiling of brain metastases in gastroesophageal cancer
  • MAPKAP Kinase 2 and ETV-1 in esophageal cancer and its metastases
  • Next generation exom sequencing of gastrointestinal stromal tumors (Cooperation University of Heidelberg)
  • MicroRNA profiling in esophageal adenocarcinoma and Barrett´s esopahgus
  • Role of MEK1/MEK2 and RAF-kinase inhibitory protein in GIST

Interdisziplinäre und inter-/nationale Kooperationen

  • ASSO (Austrian Society of Surgical Oncology)
  • NIH/NCI (Division of Cancer Epidemiology and Genetics, Bethesta)
  • Universität Heidelberg
  • T. Helbich, Small Animal Imaging Unit, Medizinische Universität Wien

Zukünftig (Grundlagenforschung)

  • Role of PTEN/PI3K/AKT pathway -activation on neoangiogenesis and cell migration in esophageal cancer
  • Influence of JAK1/JAK2 on phosphorylation of STAT3 in esophagel cancer
  • MicroRNA profiling in esophageal adenocarcinoma and Barrett´s esopahgus
  • Next generation sequencing for detection of clonal evolution of gastro-oesphageal cancer cells during neodjuvant chemotherapy
  • Inhibition of ER81/MAPKAPK2 pathway in GIST cell lines
  • Ultra deep sequencing for detection of minimal residual disease in gastroesophageal tumors
  • Crizotinib for inhibition of ALK amplificated Upper GI cell lines in vitro
  • HPV status in relation to p16 expression oesophageal cancer
  • Her-Ligands and their interaction with ERBB1 and HER2 in gastro-oesophageal cancer